Efficient algorithms for analyzing segmental duplications with deletions and inversions in genomes
نویسندگان
چکیده
منابع مشابه
Efficient Algorithms for Analyzing Segmental Duplications, Deletions, and Inversions in Genomes
Segmental duplications, or low-copy repeats, are common in mammalian genomes. In the human genome, most segmental duplications are mosaics consisting of pieces of multiple other segmental duplications. This complex genomic organization complicates analysis of the evolutionary history of these sequences. Earlier, we introduced a genomic distance, called duplication distance, that computes the mo...
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Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back into the leading...
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MOTIVATION Large-scale evolutionary events such as genomic rearrange.ments and segmental duplications form an important part of the evolution of genomes and are widely studied from both biological and computational perspectives. A basic computational problem is to infer these events in the evolutionary history for given modern genomes, a task for which many algorithms have been proposed under v...
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We show that textual analysis of microbial genomes reveal telling footprints of the early evolution of the genomes. The frequencies of word occurrence of random DNA sequences considered as texts in their four nucleotides are expected to obey Poisson distributions. It is noticed that for words less than nine letters the average width of the distributions for complete microbial genomes is many ti...
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Professor Li-Ching Hsieh Professor Liaofu Luo Professor H. C. Lee Department of Physics and Department of Life Science National Central University Chungli 320, Taiwan Department of Physics Inner Mongolia University Hohot, China Centre de Recherches Mathématiques Université de Montréal Montréal, QC, Canada Email: [email protected] The genome is a highly complex network of embedded code...
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ژورنال
عنوان ژورنال: Algorithms for Molecular Biology
سال: 2010
ISSN: 1748-7188
DOI: 10.1186/1748-7188-5-11